Hyperhomocyst(e)inemia, related vitamins and dementias.

Vitamin B12 and to a lesser extent folate deficiencies have been associated with dementias. Both these vitamins are determinants of plasma total homocysteine concentrations. In this review the frequency distributions of plasma vitamin B12, folate and homocysteine in South African males (# 51 yrs and > 51 yrs) illustrate the lower vitamin B12 levels in older subjects, and the shift […]

Read More »»

Folate, vitamin B12, and homocysteine in major depressive disorder.

Objective: The authors examined the relationships between levels of three metabolites (folate, vitamin B12, and homocysteine) and both depressive subtype and response to fluoxetine treatment in depressed patients. Methods: Fluoxetine, 20 mg/day for 8 weeks, was given to 213 outpatients with major depressive disorder. At baseline, depressive subtypes were assessed, and a blood sample was collected […]

Read More »»

Depression and dementia in aging adults with Down syndrome: a case study approach.

Patterns of symptoms associated with depression and dementia were examined in 3 aging adults with Down syndrome. A case study approach (Yin, 1994) was employed to identify and link these symptoms. Results of the case analyses provide further insight into distinguishing between depression and dementia in older persons with Down syndrome.

Read More »»