The balance of contaminant risk and nutritional benefit from maternal prenatal fish consumption for child cognitive development is not known. Using data from a prospective cohort study of 341 mother-child pairs in Massachusetts enrolled in 1999-2002, the authors studied associations of maternal second-trimester fish intake and erythrocyte mercury levels with children’s scores on the Peabody… Read More »»
Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort.
Neurodevelopmental effects of maternal nutritional status and exposure to methylmercury from eating fish during pregnancy.
Fish contain nutrients that promote optimal brain growth and development but also contain methylmercury (MeHg) that can have toxic effects. The present study tested the hypothesis that the intake of selected nutrients in fish or measures of maternal nutritional status may represent important confounders when estimating the effects of prenatal methylmercury exposure on child development.… Read More »»
Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles Child Development Nutrition Study.
Fish consumption during gestation can provide the fetus with long-chain polyunsaturated fatty acids (LCPUFA) and other nutrients essential for growth and development of the brain. However, fish consumption also exposes the fetus to the neurotoxicant, methyl mercury (MeHg). We studied the association between these fetal exposures and early child development in the Seychelles Child Development… Read More »»
Applying cost analyses to drive policy that protects children: mercury as a case study. Trasande L, Schechter C, Haynes KA, Landrigan PJ. Center for Children’s Health and the Environment, Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA. email@example.com Ann N Y Acad Sci. 2006 Sep;1076:911-23. Exposure in… Read More »»
Cognitive development in preschool children prenatally exposed to PCBs and MeHg. Stewart PW, Reihman J, Lonky EI, Darvill TJ, Pagano J. Department of Psychology, State University of New York at Oswego, Oswego, NY 13126, USA. firstname.lastname@example.org Neurotoxicol Teratol. 2003 Jan-Feb;25(1):11-22. A number of epidemiological studies have shown predictive relationships between prenatal exposure to polychlorinated biphenyls… Read More »»
The conundrum of unmeasured confounding: Comment on: “Can some of the detrimental neurodevelopmental effects attributed to lead be due to pesticides? by Brian Gulson”. Lanphear BP, Hornung RW, Khoury J, Dietrich KN, Cory-Slechta DA, Canfield RL. Cincinnati Children’s Environmental Health Center, Department of Pediatrics and of Environmental Health, Cincinnati Children’s Hospital Medical Center, The University… Read More »»
Is susceptibility to prenatal methylmercury exposure from fish consumption non- homogeneous? Tree-structured analysis for the Seychelles Child Development Study.
Studies of the association between prenatal methylmercury exposure from maternal fish consumption during pregnancy and neurodevelopmental test scores in the Seychelles Child Development Study have found no consistent pattern of associations through age 9 years. The analyses for the most recent 9-year data examined the population effects of prenatal exposure, but did not address the… Read More »»
Methylmercury and neurodevelopment: longitudinal analysis of the Seychelles child development cohort.
BACKGROUND: The Seychelles Child Development Study (SCDS) has been longitudinally following a cohort of over 700 children enrolled in 1989. Their mothers consumed a diet high in fish during pregnancy. Repeated examination of the SCDS cohort at six different ages through age 11 years has shown no pattern of adverse effects. Some early appearing beneficial… Read More »»
Do recent data from the Seychelles Islands alter the conclusions of the NRC Report on the toxicological effects of methylmercury?
In 2000, the National Research Council (NRC), an arm of the National Academy of Sciences, released a report entitled, “Toxicological Effects of Methylmercury.” The overall conclusion of that report was that, at levels of exposure in some fish- and marine mammal-consuming communities (including those in the Faroe Islands and New Zealand), subtle but significant adverse… Read More »»
Prenatal methylmercury exposure from ocean fish consumption in the Seychelles child development study.
INTRODUCTION: Exposure to methylmercury (MeHg) before birth can adversely affect children’s neurodevelopment. The most common form of prenatal exposure is maternal fish consumption, but whether such exposure harms the fetus is unknown. We aimed to identify adverse neurodevelopmental effects in a fish-consuming population. METHODS: We investigated 779 mother-infant pairs residing in the Republic of Seychelles.… Read More »»