Objective: The associations of vitamin B(12), folate, and homocysteine with depression were examined in a population-based study. Methods: The authors screened 3,884 elderly people for depressive symptoms. Subjects with positive screening results had psychiatric workups. Folate, vitamin B(12), and homocysteine blood levels were compared in 278 persons with depressive symptoms, including 112 with depressive disorders,… Read More »»
Long-term follow-up of 246 adults with juvenile idiopathic arthritis: predictive factors for mood and pain.
Objective: To examine the predictive factors for anxiety, depression and pain in adults with juvenile idiopathic arthritis (JIA). Patients and Methods: Two hundred and forty-six adults identified with long-standing JIA had an average disease duration of 28.3 yr. Candidate factors potentially predictive for pain, anxiety and depression were assessed by multiple regression analysis. Results: Of the patients,… Read More »»
Background: Pain is common among older persons and is associated with substantial disability, but factors that increase the risk for pain-related disability remain poorly defined. We sought to identify factors associated with disability due to pain in a sample of older veterans receiving primary care. Methods: Participants (N = 494) in this cross-sectional study included… Read More »»
The combination of diabetes and depression in children and adolescents is largely unstudied. The purpose of this article is to review the literature on the natural history and correlates of comorbid diabetes and depression in children and adolescents. Children with diabetes have a two-fold greater prevalence of depression, and adolescents up to three-fold greater, than… Read More »»
A major factor in the context of evaluating depression in the elderly is the role of medical problems. With aging there is a rapid increase in the prevalence of a number of medical disorders, including cancer, heart disease, Parkinson’s disease, Alzheimer’s disease, stroke, and arthritis. In this article, we hope to bring clarity to the… Read More »»
Disability, social support, and concern for children: depression in mothers with multiple sclerosis.
OBJECTIVE: To investigate the relationship between disability, concern for children, social support, and depressive symptoms in a group of mothers with multiple sclerosis (MS). DESIGN: An exploratory secondary analysis using correlation and multiple regression techniques. SETTING AND PARTICIPANTS: Two hundred one women with MS responded to a survey as part of a cohort participating in… Read More »»
Temporal and reciprocal relationship between IADL/ADL disability and depressive symptoms in late life.
A strong association between functional disability and depressive symptoms in older people has frequently been reported. Some studies attribute this association to the disabling effects of depression, others to the depressogenic effects of physical health-related disability. The authors examined the reciprocal effects between depressive symptoms and functional disability and their temporal character in a community-based… Read More »»
Low folate is associated with poorer response to selective serotonin reuptake inhibitors (SSRIs) in major depressive disorder (MDD). Folate supplementation in MDD has been studied in other settings with promising results. The objective of this study was to assess the efficacy of methylfolate as an adjunctive treatment among adults with MDD and inadequate response to an SSRI. Twenty-two adults (59%… Read More »»
Exercise and depressive symptoms: a comparison of aerobic and resistance exercise effects on emotional and physical function in older persons with high and low depressive symptomatology.
This study examines and compares the effect of aerobic and resistance exercise on emotional and physical function among older persons with initially high or low depressive symptomatology. Data are from the Fitness, Arthritis and Seniors Trial, a trial among 439 persons 60 years or older with knee osteoarthritis randomized to health education (control), resistance exercise,… Read More »»
Sertraline is a selective serotonin reuptake inhibitor (SSRI) with well established antidepressant and anxiolytic activity. Results from several well designed trials show that sertraline (50-200 mg/day) is effective in the treatment of major depressive disorder in elderly patients (> or =60 years of age). Primary endpoints in most studies included the Hamilton Depression Rating Scale… Read More »»